Giant ribbon-like platelets mimicking microfilaria in a JAK2-positive myeloproliferative neoplasm
نویسندگان
چکیده
منابع مشابه
Acute promyelocytic leukemia co-existing with JAK2 V617F positive myeloproliferative neoplasm: a case report.
The V617F mutation of Janus-associated kinase 2 (JAK2) is commonly seen in myeloproliferative neoplasms (MPN). Transformation of JAK2 positive MPNs to acute leukemia has been reported. We here report a case of acute promyelocytic leukemia which was later confirmed to have a co-existing JAK2 V617F positive MPN. In addition, the patient was found to have FLT3-TKD mutation, which, together with PM...
متن کاملTwo routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm.
Acute myeloid leukemia (AML) may follow a JAK2-positive myeloproliferative neoplasm (MPN), although the mechanisms of disease evolution, often involving loss of mutant JAK2, remain obscure. We studied 16 patients with JAK2-mutant (7 of 16) or JAK2 wild-type (9 of 16) AML after a JAK2-mutant MPN. Primary myelofibrosis or myelofibrotic transformation preceded all 7 JAK2-mutant but only 1 of 9 JAK...
متن کاملPlummer-Vinson syndrome and reactive thrombocytosis mask a JAK2-V617F positive myeloproliferative neoplasm.
A 52-year-old woman presented with abdominal pain, dysphagia, and fatigue. She had gastric adenocarcinoma treated with lower esophago-gastroduodenectomy without splenectomy and chemoradiotherapy 6 years prior. CT angiography demonstrated a thrombus in the abdominal aorta with bilateral embolic kidney infarcts, but no tumor recurrence nor organomegaly. Laboratory findings included: hemoglobin 7 ...
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1Department of Haematology, Cambridge Institute for Medical Research, Cambridge, United Kingdom; 2Institut Gustave Roussy, Inserm UMR790, Villejuif, France; 3Department of Haematology, Russell’s Hall Hospital, Dudley, United Kingdom; 4Department of Haematology, Dubrava University Hospital, Zagreb, Croatia; 5Centre for Cancer Research and Cell Biology, Queen’s University, Belfast, United Kingdom...
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REFERENCES 1. Young JL Jr, Miller RW. Incidence of malignant tumors in U. S. children. J Pediatr 1975;86:254-8. 2. Pui CH, Relling MV, Downing JR. Acute lymphoblastic leukemia. N Engl J Med 2004;350:1535-48. 3. Jonsson OG, Sartain P, Ducore JM, Buchanan GR. Bone pain as an initial symptom of childhood acute lymphoblastic leukemia: association with nearly normal hematologic indexes. J Pediatr 19...
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ژورنال
عنوان ژورنال: Hematology/Oncology and Stem Cell Therapy
سال: 2016
ISSN: 1658-3876
DOI: 10.1016/j.hemonc.2015.09.004